Samuel Little: The Most Prolific Serial Killer In U.S. History - In His Own Words Tonight on Prime Crime: Part 1 of a special two-part episode. We delve into the story of the most prolific serial killer in United States history, Samuel Little. In Part 1, we explore the killings themselves, how he escaped justice for so long, and his recorded confessions. We also speak with three of the people who actually interviewed Little, and what he had to say was frightening. #SamuelLittle #SerialKiller Best True Crime Stories Podcast 2024 Police Interrogations, 911 Calls and True Crime Investigations